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Indeed, androgen exposure, even in the absence of overt prostatic hypertrophy, elicits a coordinated pathogenic programme involving oxidative stress, endothelial dysfunction, inflammatory activation and proteomic remodeling in the ventral prostate, periprostatic adipose tissue and liver

Be honest about how to read that: the doses in those studies were milligrams per kilogram, which is orders of magnitude above anything referenced in research protocols, and dose-limiting toxicology is designed to find effects

These degradation processes involve complex physicochemical mechanisms including photo-oxidation, mechanical abrasion, hydrolytic cleavage, and microbial biodegradation, resulting in increasingly diminished particle dimensions while maintaining polymer integrity (6)